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For Permanent and Contract, Associate

    NewRef: 01/10/2022TBD_1641855992

    Research Scientist Immuno-Oncology - BOSTON - up to $120,000

    USA, Massachusetts, Boston

    • Upto 120000 USD
    • Associate Role
    • Skills: Immuno-oncology, immunology, immunological assay, IND
    • Seniority: Mid-level

    Job description

    Research Associate Scientist Immuno-Oncology - BOSTON - up to $120,000

    Research Associate Scientist Immuno-Oncology

    * Work with a company leading the way in bettering cell treatment to keep us healthy
    * Impact the cutting edge of scientific discovery and solutions through designer mRNA
    * Fantastic salary plus benefits

    What you will do:

    * Support the Immunology research
    * Support our team in working to cure diseases by bringing excellent technical experience and excitement to learn new things
    * You will report to the Director of Immunology and work closely with computational biology and mRNA delivery teams to execute on company goals

    Key requirements and responsibilities:

    * Perform in vitro immunological assay including but not limited to flow cytometry and Luminex/MSD
    * Contribute to experimental design, execution and data analysis
    * Contribute to the design and implementation of in vitro immuno-oncology studies as well as preclinical efficacy experiments and PK/PD studies for candidate selection and IND enabling studies
    * Proficient with mammalian and primary immune culture techniques and analysis of protein expression
    * Experience with animal handling, IV, IP dosing is desired
    * Experience in multi-parameter flow cytometry is desired
    * Ability to work independently and as part of a collaborative team comprised of multiple functional groups


    Additional note: even if you are not sure if you fully qualify, I'm here to talk about it! Shoot your shot!



    Location: Boston, MA (since this job is primarily lab oriented, it is fully in person)



    This opportunity will go fast, so don't miss your chance to be a part of a company that values you and the work they bring to the world! Send your resume to Taia Butler at t.butler@jeffersonfrank.com or call me at (303) 558-4356.



    Jefferson Frank is the global leader for Amazon Web Services recruitment, advertising more AWS roles than any other agency. We deal with both AWS Partners & End Users throughout North America. By specializing solely in placing candidates in the AWS market we have built relationships with most of the key employers in North America and have a complete understanding of where the best opportunities and AWS jobs are.



    Jefferson Frank is acting as an Employment Agency in relation to this vacancy.

    NewRef: 01/10/2022TBC_1641855182

    Research Assoc, mRNA - BOSTON - up to $100,000

    USA, Massachusetts, Boston

    • Upto 100000 USD
    • Associate Role
    • Skills: mRNA, HPLC, qPCR, ELISA, Fragment Analysis, Nucleic Acid
    • Seniority: Mid-level

    Job description

    Research Associate, mRNA Process Development - BOSTON - up to $100,000

    Research Associate, mRNA Process Development

    * Work with a company leading the way in bettering cell treatment to keep us healthy
    * Impact the cutting edge of scientific discovery and solutions through designer mRNA
    * Fantastic salary plus benefits

    What you will do:

    * Contribute to the development of our mRNA 2.0 platform for therapeutic applications
    * Work as part of the team responsible for the production and purification of mRNA therapeutics, analytically characterizing them, and testing them in vitro and in vivo for preclinical studies
    * Use your proficiency in mRNA chemistry and mRNA biology workflows and wet lab techniques

    Key requirements and responsibilities:

    * Synthesize and purify routine mRNA products for preclinical studies
    * Help establish and optimize our mRNA IVT manufacturing scale-up capability
    * Help develop scalable strategies for downstream product purification
    * Perform routine analytical and bioanalytical tasks such as HPLC, qPCR, ELISA, fragment analysis, mammalian cell culture, transfection, fluorescence, flow cytometry
    * Help with in vivo studies in rodents for quality validation
    * Collaborate with the Immuno-Oncology and Lipid Nanoparticle Formulation teams and execute experiments supporting the R&D pipeline
    * Analyze, summarize, and present experimental results to team members and management
    * Maintain up-to-date records and communicate results to team members in written technical reports and oral presentations
    * Interpret, summarize experimental data and maintain excellent laboratory notebooks
    * Academic or industry experience in nucleic acid manufacturing
    * Ability to analyze, summarize, and communicate scientific data
    * Preferred: Experience with automation, prior mammalian cell culture experience, familiarity with nucleic acid purification and chemistry, enzyme kinetics, and analytical characterization of biomolecules, experience with analytical techniques HPLC/UPLC, FPLC, MALDI-TOF MS, LC-MS/MS, NMR, experience with bioprocess engineering principles, process modeling, and Design of Experiment (DoE) statistical tools and GMP regulations, prior in vivo experience with mice, lipid nanoparticle drug formulation experience


    Additional note: even if you are not sure if you fully qualify, I'm here to talk about it! Shoot your shot!



    Location: Boston, MA (since this job is primarily lab oriented, it is fully in person)



    This opportunity will go fast, so don't miss your chance to be a part of a company that values you and the work they bring to the world! Send your resume to Taia Butler at t.butler@jeffersonfrank.com or call me at (303) 558-4356.

    Ref: DC242SG_1638995684

    Principal Research Associate - Boston, MA

    USA, Massachusetts, Boston

    • Upto 160000 USD
    • Other Role
    • Seniority: Senior

    Job description

    Principal Research Associate
    Location: Boston, MA



    About the company

    Early-stage start that focuses on building an AI engine for small-molecule drug discovery.



    Role & Responsibilities

    * Lab-based position responsible for designing and conducting biochemical, molecular, and cellular biology experiments within the oncology and immunology space.
    * Analyzing, interpreting, and preparing summaries of data collected and presenting internally to team members

    Skills & Qualifications

    * B.Sc + 7 years of experience OR .M.Sc + 5 years of experience
    * Hands-on proficiency with Western Blotting, biochemistry, immunofluorescence, qPCR, flow cytometry, ELISA, and other luminescence and fluorescence assay readouts.
    * Proficiency in in-vitro mammalian cell culture techniques (suspension and adherent cells), including cell line maintenance and cryopreservation.
    * Experience with running cell-based assays with small molecule inhibitors in plate-based format (e.g. 96-well).
    * Experience with cell line manipulation (siRNA, CRISPR, lentiviral transduction, transfection, stable cell line selection, clonal isolation, DNA/RNA/protein isolation etc).
    * Strong background in immunoassays including cytotoxicity and measurements of cytokine production and secretion.
    * Isolation and culture of human PBMCs.
    * Familiarity with processing animal tissue samples (e.g. blood, spleen, lymph nodes) for protein/mRNA analyses

    Benefits

    * Competitive Salary + equity
    * Professional Development and growth opportunities
    * Flexible work hours
    * Unlimited paid leave and sick time
    * 401(k) plan with employer matching
    * Healthcare, vision, dental, and life insurance plans for you and your dependents
    * Generous parental leave
    * Commuter benefits for public transportation or parking.

    Ref: KNJ353K_1641310310

    Research Associate (mRNA process development)

    USA, Massachusetts, Cambridge

    • Negotiable
    • Other Role
    • Seniority: Junior

    Job description

    Research Associate, mRNA process development Location: Cambridge, MA

    An early stage start-up that is focused on creating mRNA drugs that instruct specific cells in the body on how to make their own medicine, is actively hiring Research Associates.

    You will be part of the team responsible for the production and purification of mRNA therapeutics, analytically characterizing them, and testing them in vitro and in vivo for preclinical studies.

    Role & Responsibilities

    * Synthesize and purify routine mRNA products for preclinical studies
    * Help establish and optimize our mRNA IVT manufacturing scale-up capability.
    * Help develop scalable strategies for downstream product purification
    * Carry out process development studies using the design-of-experiments approach.
    * Perform routine analytical and bioanalytical tasks such as HPLC, qPCR, ELISA, fragment analysis, mammalian cell culture, transfection, fluorescence, flow cytometry
    * Help with in vivo studies in rodents for quality validation
    * Collaborate with the Immuno-Oncology and Lipid Nanoparticle Formulation teams
    * Analyze, summarize, and present experimental results to team members and management
    * Participate in experimental design and troubleshooting efforts

    Skills & Qualifications

    * BS/MS in Chemical Engineering, Biomedical Engineering, Chemistry, Biology, Molecular Biology, or a similar field (MS degree preferred
    * 2-5 years of academic or industry experience in nucleic acid manufacturing
    * Strong written and verbal communication skills
    * Excellent organization skills, approaching tasks with efficiency
    * Ability to analyze, summarize, and communicate scientific data

    Preferred Experience:

    * Experience with automation
    * Prior mammalian cell culture experience
    * Familiarity with nucleic acid purification and chemistry, enzyme kinetics, and analytical characterization of biomolecules
    * Experience with analytical techniques HPLC/UPLC, FPLC, MALDI-TOF MS, LC-MS/MS, NMR
    * Experience with bioprocess engineering principles, process modeling, and Design of Experiment (DoE) statistical tools and GMP regulations
    * Prior in vivo experience with mice
    * Lipid nanoparticle drug formulation experience

    Benefits

    * Competitive Salary
    * Full Benefits Package: 401k, Healthcare Coverage, Life Insurance Coverage
    * Parking and commuter benefits
    * Flexible spending account
    * Paid parental, family caregiver, medical leave

    Ref: DC242SG_1641308301

    Principal Research Associate - Boston, MA

    USA, Massachusetts, Boston

    • Upto 160000 USD
    • Other Role
    • Seniority: Senior

    Job description

    Principal Research Associate
    Location: Boston, MA



    About the company

    Early-stage start that focuses on building an AI engine for small-molecule drug discovery.



    Role & Responsibilities

    * Lab-based position responsible for designing and conducting biochemical, molecular, and cellular biology experiments within the oncology and immunology space.
    * Analyzing, interpreting, and preparing summaries of data collected and presenting internally to team members

    Skills & Qualifications

    * B.Sc + 7 years of experience OR .M.Sc + 5 years of experience
    * Hands-on proficiency with Western Blotting, biochemistry, immunofluorescence, qPCR, flow cytometry, ELISA, and other luminescence and fluorescence assay readouts.
    * Proficiency in in-vitro mammalian cell culture techniques (suspension and adherent cells), including cell line maintenance and cryopreservation.
    * Experience with running cell-based assays with small molecule inhibitors in plate-based format (e.g. 96-well).
    * Experience with cell line manipulation (siRNA, CRISPR, lentiviral transduction, transfection, stable cell line selection, clonal isolation, DNA/RNA/protein isolation etc).
    * Strong background in immunoassays including cytotoxicity and measurements of cytokine production and secretion.
    * Isolation and culture of human PBMCs.
    * Familiarity with processing animal tissue samples (e.g. blood, spleen, lymph nodes) for protein/mRNA analyses

    Benefits

    * Competitive Salary + equity
    * Professional Development and growth opportunities
    * Flexible work hours
    * Unlimited paid leave and sick time
    * 401(k) plan with employer matching
    * Healthcare, vision, dental, and life insurance plans for you and your dependents
    * Generous parental leave
    * Commuter benefits for public transportation or parking.

    NewRef: SM210122_1642776681

    AWS Solutions Architect - PreSales

    England, London

    • 90000 to 100000 GBP
    • Architect Role
    • Seniority: Senior

    Job description

    AWS PreSales Consultant/AWS Solutions Architect , £80,000-£100,000 + Bonus, London, UK - REMOTE

    I have teamed up with an AWS Premier Consulting Partner who is looking for an AWS Solutions Architect / AWS Pre-Sales Consultant.

    Required Skills

    * 3-5 years of Public Cloud experience, preferably with the AWS eco-system in a senior Presales, or senior Consulting role.
    * You will understand DevSecOps, Infrastructure as Code, and CI/CD
    * Ability to identify and understand business requirements and translate into workable technology solutions
    * Hands on ability to mock up solutions by applying your AWS skills to help customers visualise the solution
    * Have been engaged directly with customers and prospects and know how to deal with critical situations in front of clients
    * Entrepreneurial mindset, enjoy working autonomously and are a team player
    * Able to cope with unclear situations and apply common sense logic to create clear plans
    * Able to prioritise and be flexible to adapt and re-prioritise based on business needs
    * Good communication, written and oral

    Minimal Requirements

    * AWS Solutions Architect Associate Certification
    * 8 - 10 years in an IT-related Consulting role, with (ideally) some of it in a Presales function

    Please get in touch if this is of interest by sending across your latest CV at s.malik@jeffersonfrank.com and/or contact Shary Malik directly on 0191 338 7568 to have a chat.